Mental Retardation
نویسنده
چکیده
title. A book on molecular pharmacology should be concerned primarily with drug-receptor interactions in terms of small molecule-biopolymer interactions. Yet, this text discusses neither protein structure nor nucleic acid structure and minimizes discussions of drug induced conformational changes. In other words, this volume is a good textbook of nonmolecular pharmacology. In the introduction the statement is made that: "to most of the modern pharmacologists the receptor is like a beautfiul but remote lady." In the opinion of this reviewer, this statement is on the verge of being obsolete. Receptors in enzyme chemistry are not thought of in terms of beautiful ladies, but in terms of specific, interacting amino acid side chains in specific, three-dimensionally defined molecules. A text that will deal with drug-receptor interactions in molecular terms still remains to be written. The organization of the book is a rather confusing one. For instance, competitive antagonism to p-aminobenzoic acid is discussed on page 104, noncompetitive antagonism on page 436. Many other examples of closely related subjects being scattered throughout the book can be found. Fortunately, both subject index and author index are quite complete, so that in spite of this problem much of the interesting information in this book is readily accessible.
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ورودعنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 37 شماره
صفحات -
تاریخ انتشار 1965